MULTI-DRUG RESISTANCE (MDR1) GENE AND P-GLYCOPROTEIN INFLUENCE ON PHARMACOKINETIC AND PHARMACODYMANIC OF THERAPEUTIC DRUGS

Multi-drug resistance (MDR1) gene and P-glycoprotein influence on pharmacokinetic and pharmacodymanic of therapeutic drugs

(MDR1) gene expressed in tumor cells and also in several normal tissues, such as intestine, liver, kidney, blood-brain barrier, spinal cord, and placenta.P-gp has been identified in mice, rat, bovine, monkey, rodents, and human beings and has been receiving a particular clinical relevance because this protein expression limits brain access and inte

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Management style in the internal affairs bodies as one of the factors in the formation of the socio-psychological climate of the service team

The article considers the problems of choosing the optimal management style of service teams and improving management personnel in the internal affairs bodies of the Russian Federation.The aim of the research is to study the relationship between the management style and the socio-psychological climate in the team as the basis for the effectiveness

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